Torchlight 2 synergies mod embermage9/18/2023 ![]() ![]() Immolation Aura is a good defensive bonus with it’s tier.įrost Phase is essential for mobility and dodging. But if you disagree, you may spend this point in Astral Ally. To spend at least 1 skill point in Frozen Fate is mandatory for crowd control. Ice Prison is a great crowd control, so it was maxed. If you’re a noob and doesn’t know, Prismatic Bolt hits causes burn, freezes and shocks, so they trigger the brands.Įlemental Attunement is necessary because at end game you’ll spent a lot of time moving between your attacks with Prismatic Bolts, and keeping the status effects up are essential to deal a high damage with the brands (Fire Brand/Ice Brand/Lightning Brand). There weren’t points left for Prismatic Rift, but if you play it correctly you won’t need it at all.Īlthough many people says that at end game you won’t have problems with mana, Charge Mastery is great for the 25% damage bonus that embermages receive when charged, and also gives a great help with mana issues at early game.įire Brand/Ice Brand/Lightining Brand greatly increase the damge of Prismatic Bolt. After casting Hailstorm once, you’ll spam Prismatic Bolt to wipe your foes. To be honest, you even won’t use Hailstorm for AoE, you’ll just cast Hailstorm for the crowd control it causes stuning and freezing, and for the eletrical damage bonus the hailstorm tier has. ![]() ![]() Thunder Locus and Frost Wave are really good AoE, but in this build I choosed Hailstorm. Also, with the recommended pet spells you’ll have a small army for yourself and Ice Prison + Hailstorm + Frozen Fate does a great crowd control. I’ve read some reports saying that Astral Ally isn’t worth, so it was dropped. But I won’t deny that the bonuses it has are great. Torchlight 2 Elite Prismatic Bolt Embermage Guide (Wand + Shield) by ImadaĮlemental Boon has a short duration and long cooldown, so it was dropped. ![]()
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Freespace 2 download free full version9/18/2023 ![]() ![]() ![]() In adition it integrates well into launchers like Launchbox. The idea for my guide is to have a completely portable installation you can optionally put on a USB device and just plug into any machine. Let it Download in your specified directory. Open the Installer, Click Next, and choose the directory where to Install. May be something broke on Buster for this tutorial. Descent: Freespace was perhaps a tad derivative, but it was most certainly a good time, and a solid addition to Wing Commander's extended family. Knossos keeps all the mod files completely seperate from the game and only really works when used via the Knossos GUI. Select the given option to get download link. I tested full and fake KMS OpenGL driver with 256 Mb for video memory. Download (1.79 GB) Download - Easy Setup (1.54 GB) Freespace 2 screenshots: In the fall of 1998, Interplay and Volition made their entry into a market that was largely dominated by Origin & Lucasarts. For most people it is the ideal solution.īut it is not portable. If anyone is interested there are other good mods out there including BTA, B5 (Which has recently and finally been updated at long last), JAD and ASW in between others along the way. The problem is that if you have Linux Ubuntu? the Knossos thing doesn't install as of right now due to a 404 launch pad error. We have every game from the GOG.com catalog available to download for free Free GOG PC game downloads by direct link. Originally posted by Xautos:Knossos is more portable and more reliable than the FSO launcher. HLP community have dropped the game version from 3.8.x.x and went for 19.x.x instead for version numbering as well. you can play the first war and the initial aftermath campaign and then go to BP complete and play FS2 blue, then AoA and then WiH. setup can't be more simple than this.įSPort + STR and BP complete is enough to have the ideal experience. its just a lot easier to use and not half as messy on the settings.Īll you need is a fresh install of the game, get Knossos, let it download all you need after you set the correct paths and so on in the settings, then install what you want afterwards. Knossos can install whatever you want and whenever you want it, it can launch your mods without much issue rather than going into the launcher to make those changes yourself. Follow the Grand Freespace 2 Free Download PC Game Cracked in Direct Link and Torrent. The problem is that if you have Linux Ubuntu? the Knossos thing doesn't install as of right now due to a 404 launch pad error. Freespace 2 Download Full Free Updated Version 2022 - Writers Fort PC GAME Freespace 2 Download Ben Stock AugFreespace 2 Download: Set in the far-future year of 2367, Freespace 2 is an exciting first-person shooter. FreeSpace 2, the follow up to the classic Descent: FreeSpace The Great War is ready to engage you in the second round. Let it Download in your specified directory.Knossos is more portable and more reliable than the FSO launcher. Open the Installer, Click Next, and choose the directory where to Install.Ĥ. Undoubtedly one of the best 3D space combat games ever made, Freespace 2 by Volition is a superb space opera. Select the given option to get download link.ģ. A compelling tale full of twists and turnsĢ.Extremely rapid movement, a dynamic flying model, and an abundance of custom missions.Compared to other space simulations ever developed, this one is very exceptional.What’s your appetite? Take a look at the release of Freespace 2.For those that find the main game unsatisfying, have a look at some of the fantastic modifications created by other players!.Install the latest versions of your favorite games’ modifications! In Freespace 2, the FRED2 manager can be accessed through the game’s installation index. The player safeguards human and vasudan allies, but also attempts to rein in the parts of both powers (like the Hammer of Light and the Neo Terran Front) that would rather not help each other out. The game continues the story begun in Descent: FreeSpace, casting the player as a pilot tasked with defeating the Shivans, a mysterious alien invasion force. Your enemy has finally arrived… Meanwhile, they’re probably thinking about what happened to their doomed explorers. Click Below to Start Freespace 2 DownloadĪs the Terran and Vasudan races rebuild their shattered social institutions, an unsettling influence lurks in the not-so-distant compass of the Gamma Draconis framework. In a near panic, the narrator was almost swept away by the seemingly endless stream of Shivan capital ships, planes, and innovative rivals. Well, the Great War in YOUR eyes, at least. Since the end of World War One in 2367, 32 years have passed. Freespace 2 Download: World War I, In 1999, PC gamers could play FreeSpace 2 by Volition. ![]() Boxer dog breed of9/18/2023 ![]() ![]() Brindle Boxers are not rare, they are one of the three standard coloring for the Boxer breed.Ĭertain types of markings and coloring are more rare than others though, like the sealed brindle. However, white Boxers are not.The AKC determines any Boxer with more than ⅓ of their body with white markings as having white coloring and therefore disqualified by the breed standard. ![]() Brindle Boxers are recognized by the AKCīrindle Boxers and fawn Boxers are recognized by the American Kennel Club as purebred. When a Boxer has a lot of flash on their coat they’re known as flashy. Sometimes the markings go up the neck and onto the face too. Flashy Brindle Boxerīoxers often have a white underbelly and white feet. It is impossible for Boxers to have a true black coat those that appear black are actually brindle with very thick, close set black stripes. Some people try to sell these Boxers as having a black coat but that is not true. They appear black because their black stripes are sealed shut so you can see hardly any fawn at all. Now this is the rarest coloring for a Boxer out of them all. It is sometimes referred to as an inverted brindle boxer. There is, however, a rarer reverse brindle coloring with a dark background and lighter markings. The most common or “normal” brindle type is a light colored background with darker markings. Other dogs that may have brindle fur include a Greyhound, American Staffordshire Bull Terrier, Mastiff, Great Dane and Dachshund to name a few. Usually one of the colors is beige or brown and the pattern can be long stripes along the back or shorter, more disturbed stripes.īrindle Boxers are one of the most popular coloring there are, however, the colors and patterns of brindle Boxers can vary dramatically. Brindle coloring is a combination of two colors that express themselves as a pattern in the fur. Today, we’re going to be talking all about brindle Boxers.ġ. Generally, boxers have three main colors white, fawn or brindle. So now you’ve decided on a Boxer, you’ll want to decide what type of Boxer you want. Nowadays though, they make ideal family pets (as long as you can keep up with all that energy!). Boxers are a medium-sized dog that were originally bred to be guard dogs. Well, if you’ve come to this article, you may have chosen a Boxer as the ideal dog for you. There are so many breeds to choose from how do you know which one is right for you and your family? When it comes to choosing a dog, it can be overwhelming. ![]() Remote control pc mac9/18/2023 ![]() ![]() The Lock'n'Go Magnifying Glass has fantastic readability, so you can choose how large or small you want your text. Parallels is a long-loved software with a full-screen operation and a ton of tools to simplify your life when you are working remotely. ![]() Price: There are two plans for Parallels with a 14-day free trial.Compatibility: Mac, Windows, Android, iOS.It's an all-around comprehensive tool that is perfect when you need specialized access.ġ user per connection with basic featuresġ user per connection with enhanced features When you need to store files, you can use the Toolbox feature to store everything you need while running small scripts and other tasks. You can also notify end-users when you are doing maintenance so they are kept in the know. With special role-based permissions, you can choose with whom you share your private documents - even if you are assigning different roles to different people. Then, you can share files and folders with anyone you like and keep your desktop clean with a simple drag-and-drop function. You must build an access agent installer in order to gain access. With ConnectWise Control Support, unattended access works quickly and without trouble, so you can access desktops even when the user is not there. After that, there are three plans to choose from, depending on the number of connections you need to make. Price: ConnectWise offers a 14-day trial.If you see inaccuracies in our content, please report the mistake via this form. If we have made an error or published misleading information, we will correct or clarify the article. Our editors thoroughly review and fact-check every article to ensure that our content meets the highest standards. Our goal is to deliver the most accurate information and the most knowledgeable advice possible in order to help you make smarter buying decisions on tech gear and a wide array of products and services. ZDNET's editorial team writes on behalf of you, our reader. Indeed, we follow strict guidelines that ensure our editorial content is never influenced by advertisers. Neither ZDNET nor the author are compensated for these independent reviews. This helps support our work, but does not affect what we cover or how, and it does not affect the price you pay. When you click through from our site to a retailer and buy a product or service, we may earn affiliate commissions. And we pore over customer reviews to find out what matters to real people who already own and use the products and services we’re assessing. We gather data from the best available sources, including vendor and retailer listings as well as other relevant and independent reviews sites. ZDNET's recommendations are based on many hours of testing, research, and comparison shopping. ![]() White rhinoceros mass9/18/2023 ![]() “If he jumps on the cow, then we know she is ready to receive. Because females send social signals when they’re reproductively active, the behavior of males is a reliable signal. First, he alerts scientists to females who are ready and willing to reproduce. The male has two roles in the assisted reproduction process. The team selected a male who has already successfully reproduced several times and sterilized him. Leibniz Institute for Zoo and Wildlife Research, Safari Park Dvůr Králové, Kenya Wildlife Service, Ol Pejeta Conservancy, Avantea and University of Padova, Rio the photographer.Ĭounterintuitively, a living male rhino is still a participant in the whole process. Rhino care givers closely monitor southern white rhino bull Ouwan after he has been given the anaesthetic for the procedure. Recently, the team successfully implanted two embryos into a surrogate rhino and are awaiting confirmation that implantation resulted in a pregnancy. We’ve also produced southern white rhino embryos which we’re using to test how we can perform embryo transfer,” Seet said.īecause the northern white rhino embryos are so rare, the first test cases are using southern white rhino embryos. Right now, we have fourteen, they’re stored in liquid nitrogen. We use an incubator and then produce an embryo. They need the right temperature and conditions. “We have to let the embryos mature outside the body. ![]() To date, the team has successfully created 14 northern white rhino embryos utilizing Fatu’s eggs and the preserved sperm of four deceased males. Instead, the team decided they would harvest eggs, also known as oocytes, from Najin and Fatu in hopes of creating embryos which could be implanted in southern white rhino surrogates. Moreover, impregnating one or both of the remaining females necessarily locks up their biology for the duration of gestation, a period of 16 to 18 months. An ethical risk assessment suggested she may not be able to successfully carry a rhino calf to term. Najin is Fatu’s mother and is past her reproductive prime. But it isn’t as simple as implanting the two remaining females with the preserved sperm. There aren’t any living males, but their biological information still exists and could be reintroduced to the population. That’s when BioRescue realized they had sperm cells from northern white rhinos preserved in their tissue collection. Once the last of the male northern white rhinos died, the question of whether or not the species could recover on its own was settled. There are so many challenges and statistically a species will be wiped out,” Seet said. You have diseases and internal conflicts, you have catastrophes. “In our experience, if a population has less than 50 individuals, it will die out. Seet believes that in some instances meddling is exactly what needs to happen. It turns out, year by year, more species are going down the road to extinction and those databases are becoming more and more important,” Seet told SYFY WIRE.Ĭonservation efforts often focus on reducing human interference and preserving natural habitats, in order to allow a species to save themselves without our meddling in their affairs. The idea was maybe we could use the material in the future. “In the very early days our institute started to collect samples from different species and store them in liquid nitrogen. Steven Seet, a member of BioRescue’s project management and Head of Science Communication, spoke with SYFY WIRE about their efforts to save the species through assisted reproduction, utilizing preserved tissues from living and deceased white rhinos. ![]() ![]() That’s where BioRescue, an international consortium of scientists and conservationists, comes in. If things were allowed to follow their course, this subspecies of rhinoceros would vanish from the face of the Earth with the death of this last generation. Both of those individuals - named Fatu and Najin - are female, meaning there’s no chance of natural reproduction. That has been the case with the northern white rhino, a lumbering giant whose numbers have fallen so drastically that the species is functionally extinct in the wild.Īt present, there are only two northern white rhinos left. Sometimes, however, a beloved species of animal declines in numbers and we take notice. The results of that extinction are unfolding all around us, often without our having realized until it’s too late, if we even notice at all. Some scientists believe that we are currently in the midst of a sixth mass extinction event. ![]() ![]() ![]() Party, on the other hand, is for drinking parties and the likes.įinally, Dirty is for when it’s time to turn the lights off and get down and dirty. The game features over 100 questions that are separated into three categories: Fun, Party, and Dirty.įun, of course, is for casual use - for when you and your friends are a bit bored and want to have a little bit of fun. Here’s a twist on the classic favorite, “Never Have I Ever.” This game is the perfect drinking game for you and your friends (and partners)! Never Have I Ever: Dirty 18+ © Photo from Nijo Software on Google Play Store Questions can get a little bit intimate as you go along but the best part is, no one will know except the two of you.Ģ. This is a great game for adults to increase the intimacy between each other and also improve communication. This quiz game will allow couples to get a little bit more intimate as they discover things about each other that they might not have known before. IPassion is among the adult mobile games for Android that allows partners to get to know each other even better. Here’s a fun game to play with your partner. iPassion: Hot Game for Couples © Photo from iPassion ApS on Google Play Store Here are some of the best adult mobile games that you can download on Android! 1. If you think your phone is not up to par, you’d be surprised to know that it’s not difficult to find impressive gaming phones within your budget. Some games have higher system requirements that some phones can’t handle, which can affect your gaming experience. While there are many formats and approaches to what an adult mobile game is, we’ve compiled some of the best 18+ games that you can download on Android devices.īefore downloading adult mobile games for Android, it would be good to check the capacity of your phone first. These games normally center on themes that appeal to adults and contain scenes that are not for the general public to view. There are many types of adult mobile games for Android in the market today, with some coming in interactive story forms and even quiz forms. ![]() Generally speaking, adult mobile games are games that are curated for the amusement of adults. ![]() Retina detachment surgery recovering9/18/2023 ![]() ![]() This area comprises two-thirds of the volume of the eye and is called vitreous cavity, which along with the retina, the retinal pigment epithelium, choroid, and sclera, make up the posterior segment.Ī vitrectomy performed for diseases of the posterior segment is called a posterior or pars plana vitrectomy. In normal eyes, the vitreous is crystal clear throughout adulthood and fills the eye from the front or anterior (iris-lens) to the back or posterior (optic nerve). It is better to take at least 15 days off from work and other routine activities like excessive computer work etc.Posterior Pars Plana Vitrectomy: The vitreous or vitreous humor is thought to serve as a framework or support for the layers of a newborn’s eye during development.If you feel any degree of eye pain, keep pain relief tablets handy only after consulting your eye specialist.Please throw away previously opened eye drops.Always use clean and fresh tissue to clean the eye surface.Make use of eye shield for at least one week post operation.Follow and adhere to the prescription of the eye drops.Always keep your hands clean and avoid rubbing or touching your eye.Your eye surgeon will instruct you to position your head in a certain way after surgery.It is always a good idea to ask your retina specialist and take his/her approval before resuming any activity involving muscle exertion.This also includes your routine (vigorous) exercise regime, if any. As it is apparent with almost any surgery, we must restrict ourselves from doing heavy physical activities after retinal surgery as well.That’s why most doctors will insist on doing the retinal detachment surgery as soon as the diagnosis is confirmed.īesides this many a times the refractive power of the eye changes after the retinal detachment surgery due to the use of external bands and buckles which alters the length of the eye ball and silicon oil which is sometimes left inside the vitreous cavity after the retinal detachment surgery.Īfter the operation, vision can take three months or longer to improve. The longer the retina stays in a detached condition the lower the probability of near complete visual recovery. Additional factors include the delay between the occurrence of retinal detachment and the surgery. The severity of the retinal detachment determines the speed at which a patient’s vision reappears. VISUAL OUTCOME AFTER RETINAL DETACHMENT SURGERY: Typically, it takes minimum three months to ensure that the retina has been reattached firmly and for the functional visual recovery. VISION RECOVERY AFTER RETINAL DETACHMENT SURGERY:Įvery person has a different body hence, their response will vary to the treatment. For example, if any expansible gas like c3f8 has been put into the vitreous cavity then air travel is restricted for almost a month after the surgery. After the retinal detachment surgery there are several do’s and don’ts that most people have to follow for a period of a few weeks. Retinal detachment requires a retinal surgery which is performed as soon as the diagnosis is made. ![]() Curtain or a shadow spreading across your field of vision.Patients with retinal detachment usually do not feel pain, however s/he may experience.Common causes of retinal detachment include extreme nearsightedness or high myopia, eye injury, vitreous gel shrinking, post cataract surgery complications etc. RD is an eye condition wherein the back of your retina splits from the intact layers of the eyeball. One such condition is called retinal detachment (RD). ![]() Anything that interferes with the functioning of retina can turn us blind. An image is produced that is sent through optic nerve to the brain and this is what allows us to see the world around us. Light rays that travel from the object are received by the cornea and the lens and focused onto the retina. The retina is the innermost layer of our eye containing several nerves that enables us to see. ![]() Dave ramsey budget method9/18/2023 ![]() If you have chronic conditions that require routine office visits and prescription medication, you have a great starting point for this category.Įven if you and your family are the picture of health currently, this category can help you set aside money for the future. If you bike to work or take an occasional Uber, make sure you account for all those costs too. How do you move around throughout the month? Many families have at least one car, so make sure to include car payments if you have them, plus gas, parking passes, registration costs, and insurance. You also want to include your property taxes here. It also includes more than that! Whether you have renters insurance or homeowners, include that in this category. Housing includes your rent and your mortgage. This is particularly important if you live in a place where shifts in season can dramatically impact utility costs. Natural gas, water, and electricity are some of the basic utilities that you want to budget for. Think of utilities as the basic services needed to keep your home running. Many people who use Dave Ramsey percentages for the first time quickly realize that this is a category that needs their attention. This food category includes both grocery spending and eating out. Food (10% – 15%)Īre you eating your budget? A lot of people do! There’s a reason that food is part of the Big 3 Expenses people encounter. No matter where your money lands, this budget category helps you prioritize your financial future. You can also include investments, such as Roth IRAs or 401k contributions here. Saving (10%)ĭon’t let the name fool you! This category isn’t solely limited to savings accounts. Whether you tithe or perform other acts of charitable giving, this category helps budgeters set aside money each month to better their community and world. As a result, it doesn’t often get talked about. While all parts of personal finance are personal, giving is especially so. Let’s take a look at exactly what each of Dave Ramsey’s budget categories covers. That’s why Dave Ramsey percentages are so helpful: They ensure that you are looking at your complete financial picture to identify areas that you’ve mastered and places where you need to shift your focus. One of the reasons that some budgets fail is because they don’t accurately capture all of the expenses that budgeters are likely to encounter. Here’s what a Dave Ramsey budget form might look like based on his categories and percentages.
Ambar gris9/18/2023 ![]() Mechanistically, WEE1i sensitivity was associated with shortage of the dNTP pool and a concomitant increase in replication stress. When combined with olaparib, WEE1i could be differentiated from the ATRi/olaparib combination, providing distinct therapeutic strategies to overcome PARPi resistance by targeting the replication stress response. Metabolite analysis by mass spectrometry and nucleoside rescue experiments ex vivo were also conducted in patient-derived models.Īlthough WEE1i response was linked to markers of replication stress, including STK11/RB1 and phospho-RPA, ATRi response associated with ATM mutation. Biomarker analysis was conducted at the genetic and protein level. ![]() We analyzed breast and ovarian patient-derived xenoimplant models resistant to PARPi to quantify WEE1i and ATR inhibitor (ATRi) responses as single agents and in combination with PARPi. Recently, however, a PARPi/WEE1 inhibitor (WEE1i) combination demonstrated enhanced antitumor activity associated with the induction of replication stress, suggesting another approach to tackling PARPi resistance. ATR inhibition was highlighted as a unique approach to reverse both aspects of resistance. Multiple PARPi resistance mechanisms exist, most resulting in restoration of HRR and protection of stalled replication forks. PARP inhibitors (PARPi) induce synthetic lethality in homologous recombination repair (HRR)-deficient tumors and are used to treat breast, ovarian, pancreatic, and prostate cancers. 14 High Risk and Familial Cancer, Vall d'Hebron Institute of Oncology, Barcelona, Spain.13 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.12 Department of Cell Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, Oregon.11 Breast Cancer and Melanoma Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.10 Department of Medical Oncology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.9 Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.8 Growth Factors Laboratory, Vall d'Hebron Institute of Oncology, Barcelona, Spain.7 Cancer Research UK, Cambridge Institute, Cambridge, United Kingdom.6 The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom. ![]()
Turkey meatballs bread crumb substitute9/18/2023 ![]() ![]() If you go this route, make sure to do a thorough job to avoid any nasty surprises. To prepare the chips, crush them in a food processor or you can even put them in a bag and use a rolling pin to chop them up. You’ll need to coat the food in eggs and flour to make sure the chips stick to the surface. Potato chips and corn chips are both great options, but you can go more extreme with options like Doritos, BBQ Lays, or even Cheez-Its. The light crispy texture of chips makes them the perfect thing for breading. It’ll make the perfect topping for lighter poultry or fish! 5. You can convert wild rice into a breadcrumb-like texture by puffing it in a pan (similar to popcorn). ![]() Certain nuts can also be eaten in moderation by those on a keto diet. ![]() Nuts like blitz almonds, sesame seeds, and hazelnuts can be put in the food processor to make a great substitute for panko breadcrumbs.Īdditionally, they’re the perfect food for those on a paleo diet. While pretzels are not paleo, or naturally keto or gluten-free, you can buy them in keto and gluten-free varieties. What’s more, you can buy them in different varieties like honey mustard to add to the flavor of your food! Pretzels are another type of food that makes a delicious panko substitute. It’s possible to buy granola and some oats in paleo, keto, and gluten-free varieties. Cornflakes have long been used for breading entrees, but any grain-based cereal that’s not too sweet will work.Ĭorn or rice Chex, Wheaties, granola, or any oat-based cereal makes a great breading for poultry. Cereal makes a great substitute for panko bread crumbs. ![]() AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |